Journey
I am a researcher dedicated to decoding the molecular architecture of life to solve critical challenges in human disease.
My work stands at the intersection of medicine, structural biology, protein engineering, and genomics. I aim to bridge the gap between atomic-level protein dynamics and clinical outcomes, bringing a unique physician-scientist perspective to every project.
Beyond my own research, I am committed to academic leadership and mentorship, fostering a collaborative environment where new ideas (and new researchers) can thrive. My goal is not just to understand molecular mechanisms, but to translate them into innovative therapeutic strategies.
Technical Expertise
Core Competencies
Structural Biology: Ab initio modeling, structural topology, molecular mimicking, and MD simulations for both globular and membrane proteins.
Genomics & Evolution: Ancestral protein reconstruction, large-scale variant analysis, alternative splicing, and signal transduction pathways.
Mathematical Biology: Pioneering the application of Game Theory and Extensive Form Structures to genomic evolution, toolkit design, bioinformatics.
Medical Neuroscience & Immunology: Systems-level analysis of neurodegenerative pathways, immune modulation, and clinical disease mechanisms.
Methodological Toolkit
. Ab initio structure prediction, Homology modeling, QTY-variant design, Oligomer assembly prediction. Molecular Dynamics (MD), Membrane distortions, Lipid-protein interactions. Binding & Energetics, MMGBSA / MMPBSA free energy calculations, Ligand docking. Causality: Kernel causality algorithms, Confounding variable resolution. Correlation: Partial Spearman correlations, Residue co-evolution analysis. Theory: Game Theory applications, Evolutionary stability models. Evolutionary Analysis: Shannon Entropy, Purifying selection modeling, Ancestral Sequence Reconstruction (ASR). Variant Profiling: Mutational pathways, Splice-altering variation analysis. Development: Toolkit Development, Clinical Database Architecture. Wet Lab: In vitro, Assays, Protein biochemistry. Clinical Skills: Physical Examination, Patient Communication, Medical History Taking. Translational: Bridging molecular data with clinical phenotypes.
Impact & Output
30+ Submitted Research Papers. First-author publications in journals such as Pharmaceutical Research (cover article, 2024), PLoS ONE, and Journal of Molecular Evolution, with additional manuscripts under review in top-journals.
International High-impact Conference Presentations (such as European Academy of Neurology 2025, SfN Neuroscience 2025, European Human Genetics Conference 2025, Lund Spring Symposium 2025, AI for Discovery and Research Automation by Nature Machine Intelligence)
3 Patent Applications & Several Awards.
Recent experience
2022 Aug - current
Massachusetts Institute of Technology
Research Collaborator - Part Time
Laboratory of Molecular Architecture, Media Lab
> Isoforms and alternative mRNA splicing of neurotransmitter transporters
> Heteromerization and contemporary modulator design
> MSA-based protein structure prediction and computational analysis
> Extensive form games and ESS aplications in molecular events
> Structural topology and alpha helices of neuronal transporters
> Evolutionary Profiling and Natural variants analysis,
> Protein Secondary Structure Assignment, Helical structure analysis in neuronal transporter proteins
2023 Sept - 2024 Jan
University College London
Research Collaborator - Part Time
Structural Immunology Group - UCL
> Alternative mRNA splicing and structural alterations in coagulation factors
> Mutational dynamics and epistasis in disease evolution
> Phenotypical profiling and structural prediction
2023 Jan- Aug
University College London Hospitals NHS Foundation Trust
Guest Scientist - Full Time Visitor
visitor at UCL Medical School
> Evolutionarily-related proteins in Homo sapiens (Human)
> Genetic variants analysis and molecular mechanisms of related diseases
> Protein Structural Assessment of the effects of genetic variants
> Alternative splicing, and mRNA processing
> Database design with MySQL and HTML programming
