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my journey

I am a dedicated researcher with a deep fascination for the molecular/evolutionary dynamics of proteins and their impact. Specifically, understanding the structure and function of proteins, their evolution, and also their role in human diseases. I am open to new technological developments and addressing emerging medical challenges. I bring a creative and medical perspectives to research projects, introducing new ideas and providing help to research interns on computational methods and genomic tools. 

 

Beyond my academic pursuits, I am actively engaged in advocacy work, focusing on mostly planetary health, and open science. During the COVID-19 pandemic, I actively participated in translation projects to share crucial information. In my perspective, public health significantly benefits from open societies.



My skill set includes a comprehensive understanding of diverse methodologies, including structural topology, variant analysis, homology, ab initio molecular modeling, molecular neuroscience, signal transduction, alternative splicing, protein-protein/ligand interactions, molecular mimicking, ancestral protein analysis, large-scale variant analysis. Moreover, I have experience in working with neural proteins and editing medical databases. I possess experience in conducting statistical tests and correlation analysis. Through my involvement in different labs, I am acquainted with at least three distinct statistical analysis programs. One of my main focuses is applying the Game Theory and Extensive Form Structures to protein evolution. My skills extend to performing molecular dynamics simulations and multimer predictions for both globular and membranous proteins. For intricate calculations, I am familiar with various supercomputer infrastructures. I actively contribute to projects addressing modulator design for disease-linked proteins. I have more than 20 submitted research papers, several international presentations, and 3 patent applications.
 

my skill set

recent experience

2022 Aug - current

Massachusetts Institute of Technology

Research Collaborator - Part Time

Laboratory of Molecular Architecture, Media Lab

> Isoforms and alternative mRNA splicing of neurotransmitter transporters
> Heteromerization and contemporary modulator design 
> MSA-based protein structure prediction and computational analysis
> Extensive form games and ESS aplications in molecular evolution
> Structural topology and alpha helices of neuronal transporters 
> Evolutionary Profiling and Natural variants analysis, 
> Protein Secondary Structure Assignment, Helical structure analysis in neuronal transporter proteins

2023 Sept - 2024 Jan

University College London

Research Collaborator - Part Time

Structural Immunology Group- Darwin Building UCL

> Alternative mRNA splicing and structural alterations in coagulation factors
> Mutational dynamics and epistasis in disease evolution
> Phenotypical profiling and structural prediction

2023 Jan- Aug

University College London Hospitals NHS Foundation Trust

Guest Scientist - Full Time Visitor

Darwin Building in University College; visitor at UCL Medical School

> Evolutionarily-related proteins in Homo sapiens (Human)
> Genetic variants analysis and molecular mechanisms of related diseases
> Protein Structural Assessment of the effects of genetic variants
> Alternative splicing, and mRNA processing
> Database design with MySQL and HTML programming

get in touch

  • LinkedIn
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  • GitHub

The views and opinions expressed on this website are solely my own and do not reflect the views, policies, or positions of any institution, organization, or entity with which I am or have been affiliated. 

Nothing on this website should be construed as professional, legal, or official advice. 

Are you looking for Alper Karagöl?

2023 - 2025

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