Publications

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My publications

63- Karagöl T., Karagöl A. (2026) A Visual Metric for Biological Membrane Instability: Geometric Coupling of Lateral Expansion and Acyl Chain Splay as a Geometric Precursor Signature of Packing Defects in Glutamate Transporter Splice Variant Self-assemblies. (in prep)

62- Valentina N.V., Karagöl A., Karagöl T. (2026) Codon-level pH-responsive redesign of human lactoperoxidase for acidic dental formulations reveals an obligatory cofactor gate and natural precedent for pI-code substitutions. (under review)

61- Karagöl T., Karagöl A., Wickersham I.R. (2026) Paralogue Divergence and Structural Order Are Anticorrelated, Setting a Designability Ceiling for Cell-Type-Selective Protein Binders. (to be submitted)

60- Karagöl T., Karagöl A. (2026) The cost of an engineered histidine: substitution tolerance replicates across measured folding stability, variant effect prediction and curated human variation. (under review)

59- Karagöl T., Karagöl A. (2026) Codon-constrained substitution predicts charge, not tolerance: a measured functional test of a pH-responsive protein design ladder in acid-sensing ion channel 1a. (under review)

58- Karagöl T., Karagöl A. (2026) A non-transmembrane control reveals a globally permissive membrane environment in which alanine positions carry the sole distinctive polarity constraint. (under review)

57- Karagöl T., Karagöl A. (2026) Across human splice isoforms, predicted homodimers are reshaped by interface removal while added sequence is mostly disordered and seldom builds interfaces. (under review)

56- Karagöl T., Karagöl A. (2026) Two opposite failure modes in alignment-based conservation scores, one inflating and one concealing constraint, are computable before the score is used. (under review)

55- Karagöl T.*, Karagöl A.* (2026) The Apolipoprotein E N-Terminal Bundle Rendered Membrane-Compatible by Reverse-QTY Conversion Without Loss of Fold. bioRxiv https://doi.org/10.64898/2026.09.25.754306

54- Karagöl T.*, Karagöl A.* (2026) In silico directed evolution of humanized peptide transporters via computational epistatic rescue. Molecular Diversity, 1-15 https://doi.org/10.1007/s11030-026-11710-3

53- Karagöl T., Karagöl A. (2026) Dynamics-aware evolutionary profiling uncouples structural rigidity from functional motion to enable enhanced variant interpretation. Functional & Integrative Genomics 26(1):228 https://doi.org/10.1007/s10142-026-02013-9

52- Karagöl T., Karagöl A. (2026) A structural grammar of truncation across the human homodimer landscape. Nature Structural & Molecular Biology (submitted); bioRxiv https://doi.org/10.64898/2026.05.06.723091

51- Karagöl T.*, Karagöl A.* (2026) Adaptation to solvent environment in toll-like receptor 5: kernel-based evolutionary analysis of membrane-bound and soluble forms in Epinephelus coioides. Integrative Biology 18:zyag011 https://doi.org/10.1093/intbio/zyag011

50- Karagöl T., Karagöl A., Zhang S. (2026) Integrative Structural Bioinformatics and Molecular Dynamics Analyses of Synaptic Vesicle Proteins and Their Water-Soluble QTY-Variants Reveal Membrane Constraints and Evolutionary Coupling of T to V. Journal of Molecular Evolution, 1-22 https://doi.org/10.1007/s00239-026-10315-6

49- Karagöl T., Karagöl A. (2026) Microenvironmental pH and host-pathogen co-evolution potentially influence the structural architecture of junctional adhesion molecules. Molecular Genetics and Genomics 301(1):118 https://doi.org/10.1007/s00438-026-02444-w

48- Karagöl T., Karagöl A., Zhang S. (2026) Hetero-oligomerization of Odorant Receptor GPCRs with truncated splice isoforms. (in prep)

47- Karagöl T.*, Karagöl A.* (2026) Directional Variant Tension (Tv): A Causal Framework for Quantifying Substitution Asymmetry. bioRxiv (in peer review) https://doi.org/10.64898/2026.03.10.710752

46- Karagöl T., Karagöl A. (2026) Serotonin, dopamine, and norepinephrine transporter assembly is selectively disrupted by a NET truncation isoform as revealed through near-million-atom simulations. Molecular Neurobiology (in peer review); bioRxiv https://doi.org/10.64898/2026.03.25.714186

45- Karagöl T., Karagöl A. (2026) Acrylonitrile Pre-membrane Self-Assembly in Liquid Methane Under Titan-like Cryogenic Dynamics. (submitted)

44- Karagöl T.*, Karagöl A.* (2026) Alternative Splicing Guided Stoichiometric Competition Model of Vesicular Polyamine Transporter Reveals Modulatory Drug Targets. Journal of Neural Transmission (submitted) https://doi.org/10.21203/rs.3.rs-8649051/v1

43- Karagöl T., Karagöl A. (2026) High-Frequency Ratio (HFR) Metric Reveals a Complexity-Stability Relationship in Alpha-Helical Proteins. (submitted)

42- Karagöl T., Karagöl A. (2026) Integration of Fokker-Planck Dynamics and Bayesian Deep Learning for Enhanced Brain Tumor Classification. (submitted)

41- Karagöl T., Karagöl A. (2026) Simulating Silicon Life: A Computational Framework for Generating and Simulating Protease-Resistant Silicon Proteins (Silaproteins). (submitted)

40- Karagöl T., Karagöl A., Victoria A., Russell M., Galloway J. (2026) Comparative phylogenomic analysis uncovers a conserved evolutionary regime of Mycobacterium leprae in a contemporary wildlife reservoir. Nature Communications (submitted)

39- Karagöl T., Karagöl A., Victoria A., Russell M., Galloway J. (2026) Temporal switching dynamics in NHS primary-care antibacterial prescribing: a Markov-transition and Granger-causality analysis of policy-driven structural breaks. (in prep)

38- Karagöl T., Karagöl A., Victoria A., Russell M., Galloway J. (2026) The fragmentation of regional prescribing cultures in the NHS (2021-2025): a population-level phylogeographic signal analysis. (to be submitted)

37- Karagöl T., Karagöl A., Priyali S., Chan J., Russell M., Galloway J. (2026) Spatio-Temporal Dynamics, Peer Effects, and Socioeconomic Determinants in UK Topical Steroid Prescribing: A Spatial Epidemiology and Time-Series Analysis. (to be submitted)

36- Karagöl T., Karagöl A., Perkins S.J. (2026) A quantitative AI tool for predicting hemophilia factor activity levels. (in prep)

35- Karagöl T., Karagöl A. (2026) Generative design of truncated-isoform analogs identifies a critical threshold for glutamate transporter bioassembly formation. (full manuscript to be submitted after conference embargo)

34- Karagöl T., Karagöl A. (2026) Reverse-QTY Re-design of Soluble Truncated Isoforms Enhances Glutamate Transporter Bioassembly Inhibition. (full manuscript to be submitted after conference embargo)

33- Karagöl T.*, Karagöl A.* (2025) Capture of Amyloid Precursor Protein Fragments by an Engineered Water-Soluble gamma-Secretase Variant. (in peer review) https://doi.org/10.21203/rs.3.rs-8320072/v1

32- Karagöl T.*, Karagöl A.* (2025) Splice Isoform Induced Selective Inhibition of Vesicular Monoamine Transporter Assembly Revealed by Multi-level Combinatorial Analysis. Journal of Neural Transmission (submitted); bioRxiv https://doi.org/10.1101/2025.11.29.691296

31- Karagöl T., Karagöl A., Perkins S.J. (2025) Alternative Splicing Induced Mutational Bypass of Factor IX Modulates Peptide Binding Stability: A Combinatorial Multi-Omics Study. (to be submitted)

30- Karagöl T.*, Karagöl A.* (2025) A Conserved Motif as an Evolutionary Kernel for beta-Sheet Oligomerization Revealed by Divergence Analysis of Helix-to-Sheet Transitions in EAA1 Isoforms. bioRxiv https://doi.org/10.1101/2025.10.02.679742

29- Karagöl T., Karagöl A. (2025) What Do Membrane Proteins Really Want?. Springer Nature, Behind the Paper https://go.nature.com/3KnbhdB

28- Karagöl T.*, Karagöl A.* (2025) Helix-to-Beta-Sheet Transition Drives Self-Assembly of Glutamate Transporter EAA1 Splice Peptides. (under review); bioRxiv https://doi.org/10.1101/2025.08.13.670123

27- Karagöl T., Karagöl A. (2025) pH-Dependent Membrane Binding Specificity of Synaptogyrins 1-3 Provides Mechanistic Insights into Synaptic Vesicle Regulation and Neurological Disease. European Biophysics Journal (under review); bioRxiv https://doi.org/10.1101/2025.03.03.641025

26- Karagöl T., Karagöl A. (2025) Cross-reactivity of glutamate transporter EAA1 and truncated EAA2 isoforms revealed via structural neuroinformatics. European Journal of Neurology 32(S1):186-187 https://doi.org/10.1111/ene.70191

25- Karagöl T.*, Karagöl A.* (2025) Water-soluble QTY variant of the gamma-secretase complex provides insights into amyloid precursor protein recognition. European Journal of Neurology 32(S1):69-70 https://doi.org/10.1111/ene.70191

24- Karagöl T., Karagöl A., Spencer H., Xu Z., Perkins S.J. (2025) A genomic upgrade to 2139 genetic variants in the interactive coagulation factor IX database provides enhanced insights into hemophilia B. European Journal of Human Genetics 33:734 https://doi.org/10.1038/s41431-025-01932-8

23- Karagöl T.*, Karagöl A.*, Perkins S.J. (2025) A kernel causality analysis of evolutionary amino acid changes reveals extensive nodes of coagulation factor IX variants in the development of haemophilia B. European Journal of Human Genetics 33:1130 https://doi.org/10.1038/s41431-025-01932-8

22- Karagöl T., Karagöl A., Li M., Zhang S. (2025) Computational Data Driven Methods in Discovery of Native Neurological Transporter Modulators. Nature Conferences: AI for Discovery and Research Automation

21- Karagöl T., Karagöl A. (2025) Computational Design of Lipid-soluble ApoE N-terminal Segment Using Reverse-QTY Code. SfN Neuroscience 2025 https://www.sfn.org/meetings/neuroscience-2025

20- Karagöl T., Karagöl A. (2025) Evolutionary Divergence of Helix-to-Sheet Transformation in EAA1 splice homologs. Journal of Molecular Evolution (under review)

19- Karagöl T., Karagöl A. (2025) Kernel Regression and Stochastic Dominance Analysis Unveil Asymmetric Residue-wise Evolutionary Dynamics of Coagulation Factors F9 and F8. (full manuscript to be submitted after conference embargo)

18- Karagöl T., Karagöl A., Zhang S. (2025) Co-evolution of alpha-helical transmembrane protein residues: large-scale variant profiling and complete mutational landscape of 2277 known PDB entries representing 504 unique human protein sequences. Journal of Molecular Evolution 93(5):581-599 https://doi.org/10.1007/s00239-025-10262-8

17- Sajeev-Sheeja A., Karagöl A., Karagöl T., Zhang S. (2025) Molecular dynamics simulations and structural bioinformatics of bacterial integral alpha-helical membrane enzymes and their AlphaFold2-predicted water-soluble QTY analogues. Molecular Simulation 51(15):984-998 https://doi.org/10.1080/08927022.2025.2562932

16- Johnsson F., Karagöl A., Karagöl T., Zhang S. (2025) Structural bioinformatic study of six human olfactory receptors and their AlphaFold3 predicted water-soluble QTY variants and OR1A2 with an odorant octanoate and TAAR9 with spermidine. QRB Discovery 6:e2 https://doi.org/10.1017/qrd.2024.18

15- Karagöl T., Karagöl A., Zhang S. (2025) Multi-level Comparative Genomic Analysis Reveals Evolutionary Influence of Truncated Isoforms in Glutamate Transporter Genes. Journal of Molecular Evolution (under review)

14- Perkins S.J., Karagöl T., Karagöl A., Spencer H. (2025) Factor IX Variant Database 2024 version: genetic variants in human coagulation factor 9 as a service for clinicians and biochemists. Structural Immunology Group, University College London

13- Karagöl T., Karagöl A. (2024) Regulation of Immune Activation and Inflammatory Response with a Truncated STING Isoform for the Treatment of Autoimmune Diseases and Inflammation. TR Patent application 2024/018993

12- Karagöl T.*, Karagöl A.* (2024) A Method for Designing pH-Specific Proteins with High Topological Similarity Using Serial Consecutive Single Nucleotide Variations. TR Patent application 2024/018998

11- Karagöl T., Karagöl A. (2024) Use of a Truncated Isoform of the VAMP2 Protein in the Treatment of Neurological Diseases and Neuromodulation Applications. TR Patent application 2024/018735

10- Karagöl T.*, Karagöl A.* (2024) Molecular dynamic simulations reveal that water-soluble QTY-variants of glutamate transporters EAA1, EAA2 and EAA3 retain the conformational characteristics of native transporters. Pharmaceutical Research 41(10):1965-1977 https://doi.org/10.1007/s11095-024-03769-0

9- Karagöl T.*, Karagöl A.*, Li M., Zhang S. (2024) Inhibitory Potential of the Truncated Isoforms on Glutamate Transporter Oligomerization Identified by Computational Analysis of Gene-Centric Isoform Maps. Pharmaceutical Research 41(11):2173-2187 https://doi.org/10.1007/s11095-024-03786-z

8- Karagöl T., Karagöl A. (2024) Benchmarking GROMACS on optimized Colab processors and the flexibility of cloud computing for molecular dynamics. Journal of Molecular Modelling (submitted); bioRxiv https://doi.org/10.1101/2024.11.14.623563

7- Karagöl T.*, Karagöl A.* (2024) An Evolutionary Statistics Toolkit for Simplified Sequence Analysis on Web with Client-Side Processing. Journal of Applied Genetics (submitted); bioRxiv https://doi.org/10.1101/2024.08.01.606148

6- Karagöl T., Karagöl A., Zhang S. (2024) Structural bioinformatics studies of serotonin, dopamine and norepinephrine transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L to Q, I to T, F to Y and Q to L, T to I and Y to F. PLoS ONE 19(3):e0300340 https://doi.org/10.1371/journal.pone.0300340

5- Karagöl T.*, Karagöl A.*, Smorodina E., Zhang S. (2024) Structural bioinformatics studies of glutamate transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L to Q, V to T, F to Y and vice versa. PLoS ONE 19(4):e0289644 https://doi.org/10.1371/journal.pone.0289644

4- Karagöl T., Karagöl A. (2023) A genomic and structural analysis provides enhanced insights into molecular mechanisms of hemophilia B. Journal of Thrombosis and Haemostasis (under review)

3- European Medical Student Association Medical Science Small Working Group (2020) Medical Science 101 Booklet. EMSA Medical Science https://www.researchgate.net/publication/364097927_Medical_Science_101_Booklet

2- Karagöl T. (2020) COVID-19 Information Project, volunteer translator. Istanbul University https://www.istanbul.edu.tr/tr/content/covid-19-bilgilendirme-sayfasi/bilgi-seferberligi-projesi-cevirileri

1- Karagöl T. (co-first author), Karagöl A. (2018) Multipl sklerozun olasi tedavisi icin in silico makromolekul dizayni ve hesaplamali analizi. Google Science Fair https://www.googlesciencefair.com/projects/2018/db7a23df00c2891d75b5a625e5d9

* co-first authors

Talks & symposium proceedings

34. The Protein Society Annual Symposium, Boston, USA - Karagöl Taner, Karagöl Alper, Shuguang Zhang (2026). Systematic Redesign of Synaptic Vesicle Proteins into Water-Soluble Variants via the QTY-Code Reveals Key Conformational and Evolutionary Dynamics (Award Winner)

33. The Protein Society Annual Symposium, Boston, USA - Karagöl Taner, Karagöl Alper, Shuguang Zhang (2026). Multi-Level Comparative Genomic Analysis Reveals Functional Influence of Truncated Isoforms in Glutamate Transporter Genes (Award Winner)

32. 12th European Academy of Neurology Annual Congress. Geneva, Switzerland. - Karagöl Taner, Karagöl Alper (2026). Lipid Induced Energetic Lability in Serotonin and Dopamine Transporter Assembly Could Be Resisted by Truncation Isoforms.

31. 12th European Academy of Neurology Annual Congress. Geneva, Switzerland. - Karagöl Taner, Karagöl Alper (2026). Reverse-QTY Engineering Converts Soluble Glutamate Transporter Isoforms into High-Affinity Inhibitors.

30. 2026 European Human Genetics Conference organized by the European Society of Human Genetics (ESHG). Gothenburg, Sweden. - Karagöl Taner, Karagöl Alper (2026) Generative Design of Splice Variant Analogs Identifies a Critical Chain Length Threshold for Glutamate Transporter Assembly Loss-of-Function (Poster)

29. 2026 European Human Genetics Conference organized by the European Society of Human Genetics (ESHG).Gothenburg, Sweden. - Karagöl Taner, Karagöl Alper (2026) Improved Interpretation of Human Genetic Variation through Dynamics-Aware Evolutionary Profiling (Poster)

28- Karagöl Taner, Karagöl Alper, Li Mengke, Zhang Shuguang (2025). Computational Data Driven Methods In Discovery Of Native Neurological Transporter Modulators. (Speaker) Nature Conferences - AI for Discovery and Research Automation Conference, organized by Nature Machine Intelligence

27. 29th International Medical Sciences Congress organised by Istanbul University. Gül Kaan Murat, Karagöl Taner, Karagöl Alper. A Next-Generation Approach to Neuroinflammation Modulation: Computational Identification of Inhibitory Truncated Isoforms for Neuroimmunological Targets. (Supervisor)

26. 29th International Medical Sciences Congress organised by Istanbul University. Eken Çınar, Karagöl Alper, Karagöl Taner. Acid-Switchable BRC4-Derived Peptides as Selective Rad51 Inhibitors for Sensitization of Homologous Recombination-Proficient Tumors (Supervisor)

25 - 29th International Medical Sciences Congress organised by Istanbul University. Karagöl Taner. Lecture Title: New Horizons in Medical Sciences (Distinguished Speaker)

24- Karagöl Taner, Karagöl Alper (2025). Variant Dynamics of the Molecular Environment. (Speaker) Sixth International Conference on Proteins and Peptides, Structure, Function, and Biotechnology, co-organized by Menicon, MIT, and the University of Geneva, Geneva, Switzerland

23- Karagöl Taner, Karagöl Alper (2025). Evolutionary Dynamics of Membrane Proteins Through Water-Soluble Variants. (Speaker) Sixth International Conference on Proteins and Peptides, Structure, Function, and Biotechnology, co-organized by Menicon, MIT, and the University of Geneva, Geneva, Switzerland

22. Neuroscience 2025 (SfN Annual Meeting). San Diego -Karagöl Alper, Karagöl Taner. Helix-to-β-Sheet Transitions in Glutamate Transporter EAA1 Splice Isoforms Drive Oligomeric Self-Assemblies and Reveal Conserved Evolutionary Motifs (Late-breaking, free-waiver winner)

21. Neuroscience 2025 (SfN Annual Meeting). San Diego -Karagöl Taner, Karagöl Alper. Computational design of lipid-soluble ApoE N-terminal segment using reverse-QTY code (Late-breaking, free-waiver winner)

20- Karagöl Taner Lecture Title: Biological Machines in Molecular Nanotechnology BORASTEM’25 Festival at Marmara University, Istanbul. Public Engagement of Science - (Distinguished Speaker)

19- Karagöl Taner (Speaker) Neuroscience Conference Experiences 10 July 2025 R&D and Innovation Supreme Coordination Office, Istanbul University, Turkey

18- Karagöl Taner, Karagöl Alper, (2025). Water-Soluble QTY Variant of the Gamma-Secretase Complex Provides Insights into Amyloid Precursor Protein Recognition. (Presentation-Oral) 11th European Academy of Neurology Annual Congress. Helsinki, Finland. GRANT WINNER

17- Karagöl Taner, Karagöl Alper (2025). Cross-Reactivity of Glutamate Transporter EAAT1 and Truncated EAAT2 Isoforms Revealed via Structural Neuroinformatics (Presentation-Oral) 11th European Academy of Neurology Annual Congress. Helsinki, Finland. GRANT WINNER

16- Karagöl Taner, Karagöl Alper, (2025). Karagöl Alper, Karagöl Taner. Computational design of lipid-soluble ApoE N-terminal segment using reverse-QTY code. Neuroscience 2025 (SfN Annual Meeting). San Diago, USA. Late-breaking

15- Karagöl Taner, Karagöl Alper, (2025). Karagöl Alper, Karagöl Taner. Helix-to-β-Sheet Transitions in Glutamate Transporter EAA1 Splice Isoforms Drive Oligomeric Self-Assemblies and Reveal Conserved Evolutionary Motifs. Neuroscience 2025 (SfN Annual Meeting). San Diago, USA. Late-breaking

14- Karagöl Taner, Karagöl Alper, (2025). Multi-Level Comparative Genomic Analysis Reveals Functional Influence of Truncated Isoforms in Glutamate Transporter Genes. Sixth International Conference on Proteins and Peptides, Structure, Function, and Biotechnology, co-organized by Menicon, MIT, and the University of Geneva, Geneva, Switzerland (Poster)

13- Karagöl Taner, Karagöl Alper, Perkins S.J. (2025) A Kernel Regression and Analysis of Evolutionary Amino Acid Varieties Reveals Extensive Nodes of Coagulation Factor 9 variants in the development of Hemophilia B (Poster) 2025 European Human Genetics Conference organized by the European Society of Human Genetics (ESHG). Milan, Italy.

12- Karagöl Taner, Karagöl Alper, Spencer H., Perkins S.J. (2025) A genomic and structural analysis provides enhanced insights into molecular mechanisms of hemophilia B. (Poster) 2025 European Human Genetics Conference organized by the European Society of Human Genetics (ESHG). Milan, Italy.

11- Karagöl Taner, Karagöl Alper, Shuguang Zhang (2025). Structural Bioinformatic Studies of Synaptic Vesicle Proteins with Their Alphafold3 Predicted Water-Soluble QTY Variants and Uncovering the T<=>V Co-Evolution - The 2nd Lund Spring Symposium: Enabling Novel Therapeutic Principles. Lund University, Sweden (Poster presentation)

10- Karagöl Taner, Karagöl Alper, Shuguang Zhang (2025). Multi-Level Comparative Genomic Analysis Reveals Functional Influence of Truncated Isoforms in Glutamate Transporter Genes The 2nd Lund Spring Symposium: Enabling Novel Therapeutic Principles. Lund University, Sweden (Poster presentation)

9- Karagöl Alper, Karagöl Taner, Shuguang Zhang (2024). Comparative genomic analysis of glutamate transporters reveals the evolutionary landscape and splicing plasticity of truncated isoforms. Poster at the 2024 KSBNS Annual Meeting co-organized by Korean Society for Brain and Neural Sciences and the Asian-Pacific Society for Neurochemistry. Gyeongju, South Korea. FELLOWSHIP WINNER

8 - Karagöl Taner, Karagöl Alper, Mengke Li, Shuguang Zhang (2024). Inhibitory effects of the truncated isoforms on glutamate transporter oligomerization revealed by the analysis of gene-centric isoform maps. Poster at the 2024 KSBNS Annual Meeting co-organized by Korean Society for Brain and Neural Sciences and the Asian-Pacific Society for Neurochemistry. Gyeongju, South Korea. FELLOWSHIP WINNER

7- Karagöl Taner, Karagöl Alper, Smorodina Eva, Shuguang Zhang (2024, 1-3 March). Structural studies of glutamate transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural QTY-code mutations. Poster presented at the XXI. International IUGEN Winter School on Molecular Biology and Genetics- Istanbul University, Istanbul, Turkey

6- Taner Karagöl, Alper Karagöl, Shuguang Zhang (2024, April). Evolutionary and structural comparison of serotonin, dopamine and norepinephrine transporters and their water-soluble QTY variants. Oral Presentation at the 28th International Medical Sciences Student Congress (IMSSC) -Istanbul University, Istanbul Turkey

5- Karagöl Alper, Karagöl Taner, Smorodina Eva, Shuguang Zhang (2023). Structural bioinformatics studies of glutamate transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F. Poster presented at the fifth International Conference on Proteins and Peptides, Structure, Function, and Biotechnology, co-organized by Menicon, MIT, and the University of Geneva, Geneva, Switzerland

4- Karagöl, H.A. and Karagöl, M.T. (2018).In silico macromolecule design and computational analysis for possible treatment of multiple sclerosis [Multipl sklerozun olası tedavisi için in silico makromolekül dizaynı ve hesaplamalı analizi]. Attended to Google Science Fair 2018-2019.

3- Karagöl, H.A. and Karagöl, M.T. (2017). In silico macromolecule design and competition analysis for treatment of multiple sclerosis [Multiple Skleroz Hastalığının Olası Tedavisi için in silico Makromolekül Dizaynı ve Hesaplamalı Analizi]. Presentation to BAYER - Turkey Science Projects competition

2- Karagöl, H.A. and Karagöl, M.T. (2017). Multiple Skleroz Hastalığının Araştırılmasında Moleküler Modellemenin Kullanımı [Utilization of molecular modeling in Multiple Sclerosis research], 49th TUBITAK (Scientific and Technological Research Council of Turkey) Research Projects competition. https://www.tubitak.gov.tr/en/competitions/content-2204-a-high-school-students-research-projects-competition

1- Educational Presentations on Endocrinology and Computational Biology (2020-2024), Istanbul University Student Scientific Research Club.

Selected honours & awards

Anthropic AI for Science program. Protein-triggered genetic switches from de novo designed binder pairs. MIT McGovern Institute for Brain Research.

Protein Society Young Investigator Travel Award (2026) : Granted by The Protein Society for the upcoming Annual Symposium in Boston.

Scientific Research Award in Health Sciences (2026) : Awarded by the Istanbul University Rectorate for outstanding contributions to biomedical research.

Dean’s Award for Scientific Excellence 2025, Istanbul University. This recognition is reserved for top-performing students who have demonstrated outstanding research achievements during medical training. Issued for my work on "Developing New Therapeutic Strategies Targeting the Molecular Architecture of Neuronal Transporters”.

Ministry of Industry and Technology, Turkish Patent Office PatentleTürkiye Grants awarded for my patents: "Method for Designing Ph-Specific Proteins Using Evolutionary Informed Sequential Single Base Substitutions.", "Regulation of Immune Activation and Inflammatory Response with STING Truncated Isoform for The Treatment of Autoimmune Diseases and Inflammation.", "Inhibition of Snare Complex Formation and VAMP2 Dimerization by The VAMP2 Truncated Isoform, Targeting Pain Management, Neuromuscular Blockade, and Synaptic Modulation.

The European Academy of Neurology (2025) - Congress Bursary Awarded to my work titled "Cross-Reactivity of Glutamate Transporter EAAT1 and Truncated EAAT2 Isoforms Revealed via Structural Neuroinformatics".

Scientific and Technological Research Council of Turkey, Scientist Support Programs - 2224 International Scientific Meetings Fellowship Program (2024) for “presenting proceedings in scientific meetings abroad to share their original studies with the world of science”. - Fellowship

Erich Frank Scholarship (Alternate Recipient) – Erich-Frank-Gesellschaft, Universität München, Germany (2022). - Recognition of academic merit, to conduct an internship in Germany. The award named after Prof. Dr. med. Ephraim (Erich) Frank (1884–1957), a physician who modernized internal medicine in Istanbul. (not attended as alternate recipient in the internship, pursued another opportunity).

Scientific and Technological Research Council of Turkey (TUBITAK) 25th Biology Olympiad 13 May 2017: first place🥇in the Marmara Region (including Istanbul and Bursa), fifth in Turkey

Istanbul University Istanbul Medical Faculty English Program, settled with honors (top 15, each year >450 students enroll to medical program)

National Higher Education Institutions Exam (YKS) 2018 - top 0.02% out of 2,381,090

Graduated from the high school summa cum laude. High school, top university entrance 🥇

BAYER - Turkey High School Science Projects competition Certificate of Achievement (Jan 2017)

Several Medical - Undergraduate Educational Scholarships 2018 – 2026

Republic of Turkey Ministry of National Education - 2011 Scholarship exam🏅 for Primary and secondary education institutions - Scholarship (2012 – 2018) Scholarship Duration: 7 years