Publications

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My publications

43 - Karagöl T, Karagöl A. (2026) A structural grammar of truncation across the human homodimer landscape. Nature Structural & Molecular Biology (submitted) https://doi.org/10.64898/2026.05.06.723091

42- Karagöl T., Karagöl A. (2026) Adaptation to Solvent Environment in Toll-like Receptor 5: A Comparative Evolutionary Analysis of Membrane-bound and Soluble Forms in Epinephelus coioides. Integrative Biology (In Press) https://doi.org/10.1101/2025.02.28.640895

41- Karagöl, T., Karagöl, A., & Zhang, S. (2026). Integrative Structural Bioinformatics and Molecular Dynamics Analyses of Synaptic Vesicle Proteins and Their Water-Soluble QTY-Variants Reveal Membrane Constraints and Evolutionary Coupling of T ⇔ V. Journal of Molecular Evolution. https://doi.org/10.1007/s00239-026-10315-6

40- Karagöl T., Karagöl A. (2026) Microenvironmental pH and Host-Pathogen Co-evolution Potentially Influence the Structural Architecture of Junctional Adhesion Molecules. Molecular Genetics and Genomics https://doi.org/10.1007/s00438-026-02444-w

39- Karagöl T., Karagöl A., Zhang S. (2026). Hetero-oligomerization of Odorant Receptor GPCRs with truncated splice isoforms. (in prep)

38- Karagöl, T., Karagöl, A. (2026) In Silico Directed Evolution of Humanized Peptide Transporters via Attention-Guided Epistatic Rescue (in peer review) https://doi.org/10.21203/rs.3.rs-9198655/v1

37 - Karagöl T, Karagöl A. (2026) Directional Variant Tension (Tᵥ): A Causal Framework for Quantifying Substitution Asymmetry (in peer review) https://doi.org/10.64898/2026.03.10.710752

36- Karagöl T., Karagöl A. (2026). Serotonin, dopamine, and norepinephrine transporter assembly is selectively disrupted by a NET truncation isoform as revealed through near-million-atom simulations. ACS Chemical Neuroscience (in peer review) https://doi.org/10.64898/2026.03.25.714186

35- Karagöl T., Karagöl A. (2026). Dynamics-aware Evolutionary Profiling Uncouples Structural Rigidity from Functional Motion to Enable Enhanced Variant Interpretation. Functional & Integrative Genomics (in peer review) https://doi.org/10.64898/2026.01.16.699945

34- Karagöl T., Karagöl A. (2026) Acrylonitrile Pre-membrane Self-Assembly in Liquid Methane Under Titan-like Cryogenic Dynamics (submitted)

33- Karagöl T, Karagöl A. (2026) Alternative Splicing Guided Stoichiometric Competition Model of Vesicular Polyamine Transporter Reveals Modulatory Drug Targets Journal of Neuronal Transmission (submitted) https://doi.org/10.21203/rs.3.rs-8649051/v1

32- Karagöl T, Karagöl A. (2026) High-Frequency Ratio (HFR) Metric Reveals a Complexity–Stability Relationship in Alpha-Helical Proteins (submitted)

31- Karagöl T., Karagöl A. (2026) Integration of Fokker-Planck Dynamics and Bayesian Deep Learning for Enhanced Brain Tumor Classification. (submitted)

30- Karagöl T., Karagöl A. (2025) Capture of Amyloid Precursor Protein Fragments by an Engineered Water-Soluble γ-Secretase Variant (in peer review) https://doi.org/10.21203/rs.3.rs-8320072/v1

29- Karagöl T., Karagöl A.. (2025) Computational Design of Lipid-soluble ApoE N-terminal Segment Using Reverse-QTY Code (full manuscript to be submitted after conference embargo). https://www.sfn.org/meetings/neuroscience-2025

28- Karagöl T., Karagöl A. (2025). Splice Isoform Induced Selective Inhibition of Vesicular Monoamine Transporter Canonical Assembly Revealed by Multi-level Combinatorial Analysis Journal of Neural Transmission.(submitted) https://doi.org/10.1101/2025.11.29.691296

27-Karagöl T., Karagöl A., Perkins SJ. (2025) Alternative Splicing Induced Mutational Bypass of FactorIX Modulates Peptide Binding Stability: A Combinatorial Multi-Omics Study (to be submitted)

26- Karagöl T., Karagöl A.(2025) A Conserved Motif as an Evolutionary Kernel for β-Sheet Oligomerization Revealed by Divergence Analysis of Helix-to-Sheet Transitions in EAA1 Isoforms https://doi.org/10.1101/2025.10.02.679742

25- Karagöl T., Karagöl A. (2025). What Do Membrane Proteins Really Want?. Springer Nature Behind the Paper https://go.nature.com/3KnbhdB

24- Karagöl T., Karagöl A. (2025) Helix-to-Beta-Sheet Transition Drives Self-Assembly of Glutamate Transporter EAA1 Splice Peptides (under review) https://doi.org/10.1101/2025.08.13.670123

23- Karagöl T, Karagöl A. (2025) pH-Dependent Membrane Binding Specificity of Synaptogyrins 1-3 with Distinct Isoelectric Points (pI) Identified by Structural Bioinformatics and Molecular Dynamics - European Biophysics Journal (Under review) https://doi.org/10.1101/2025.03.03.641025

22- Karagöl T., Karagöl A. (2025) Cross-Reactivity of Glutamate Transporter EAAT1 and Truncated EAAT2 Isoforms Revealed via Structural Neuroinformatics- European Journal of Neurology Special Issue https://doi.org/10.1111/ene.70191

21- Karagöl T, Karagöl A. (2024) Regulation of Immune Activation and Inflammatory Response with STING Truncated Isoform for The Treatment of Autoimmune Diseases and Inflammation. Patent application No: 2024/018993. The early publication request has been approved. Patent application No: 2024/018993.

20- Karagöl T, Karagöl A. (2024) Method for Designing Ph-Specific Proteins Using Evolutionary Informed Sequential Single Base Substitutions. The early publication request has been approved. Patent application No: 2024/018998.

19- Karagöl T., Karagöl A. (2024) Inhibition of Snare Complex Formation and VAMP2 Dimerization by The VAMP2 Truncated Isoform, Targeting Pain Management, Neuromuscular Blockade, and Synaptic Modulation. Patent application No: 2024/018735. The early publication request has been approved. Patent application No: 2024/018735.

18- Karagöl T, Karagöl A. (2025) Water-Soluble QTY Variant of the Gamma-Secretase Complex Provides Insights into Amyloid Precursor Protein Recognition European Journal of Neurology Special Issue https://doi.org/10.1111/ene.70191

17- Karagöl T., Karagöl A., Zhang S. (2024) Molecular Dynamic simulations reveal that water-soluble QTY-variants of glutamate transporters EAA1-3 retain the conformational characteristics of native transporters. Pharmaceutical Research. PMCID: PMC39322794 https://doi.org/10.1007/s11095-024-03769-0

16- Karagöl T., Karagöl A. (2024). Benchmarking GROMACS on Optimized Google Colab Processors and the Flexibility of Cloud Computing for Molecular Dynamics. Journal of Molecular Modelling. (Submitted) https://doi.org/10.1101/2024.11.14.623563

15- Karagöl T, Karagöl A, Zhang S. (2024). Co-evolution of Alpha-helical Transmembrane Protein Residues: Large-Scale Variant Profiling and Complete Mutational Landscape of 2277 known RCSB Entries Representing 504 UniProt Sequences. Journal of Molecular Evolution PMID: 40993375 https://doi.org/10.1007/s00239-025-10262-8

14- Karagöl T., Karagöl A. Kernel Regression and Stochastic Dominance Analysis Unveil Asymetric Residue-wise Evolutionary Dynamics of Coagulation Factors F9 and F8 (full manuscript to be submitted after conference embargo).

13- Johnsson F., Karagöl T., Karagöl A., Zhang S. (2024). Structural bioinformatics studies of olfactory receptors, TAAR9and their AlphaFold3 predicted water-soluble QTY variants and odorant binding. QRB Discovery https://doi.org/10.1017/qrd.2024.18

12- Akash S., Karagöl T., Karagöl A., Zhang S. (2024) Structural bioinformatics of bacterial integral alpha-helical membrane enzymes and their AlphaFold2 predicted water-soluble QTY variants. Molecular Simulation https://doi.org/10.1080/08927022.2025.2562932

11- Karagöl T., Karagöl A., Zhang S.(2024) Multi-level Comparative Genomic Analysis Reveals Evolutionary Influence of Truncated Isoforms in Glutamate Transporter Genes Human Genetics. Journal of Molecular Evolution (Under Review)

10- Karagol, T., & Karagol, A. (2024). An Evolutionary Statistics Toolkit for Simplified Sequence Analysis on Web with Client-Side Processing. Journal of Applied Genetics (submitted) https://doi.org/10.1101/2024.08.01.606148

9- Karagöl T., Karagöl A., Zhang S. (2024) Molecular Dynamic simulations reveal that water-soluble QTY-variants of glutamate transporters EAA1-3 retain the conformational characteristics of native transporters. Pharmaceutical Research.

PMCID: PMC39322794

8- Karagöl T., Karagöl A., Li M., Zhang S. (2024) Inhibitory effects of the truncated isoforms on glutamate transporter oligomerization revealed by the analysis of gene-centric isoform maps. Pharmaceutical Research PMID: PMC39487385

7- Karagöl T., Karagöl A., Zhang S. (2024) Structural bioinformatics studies of serotonin, dopamine and norepinephrine transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F. PL0S ONE PMCID: PMC10959339

6- Karagöl et. al. A genomic and structural analysis provides enhanced insights into molecular mechanisms of hemophilia B. Journal of Thrombosis and Haemostasis. (Under review, Aug 2023)

5- Perkins S.J, Karagöl T., Karagöl A., Spencer H. Factor IX Variant Database 2024 version: Genetic variants in the human coagulation factor 9 as a service for clinicians and biochemists. © Copyright 2003-2023, Structural Immunology Group, University College London (2003- 2025) (To be published)

4- Taner Karagöl, Alper Karagöl, Eva Smorodina, & Shuguang Zhang. (2023) Structural bioinformatics studies of glutamate transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, V->T, F->Y and vice versa. PLoS ONE. PMCID: PMC11006163

3- European Medical Student Association Medical Science Small Working Group (2020). Medical Science 101 Booklet (2020), EMSA Medical Science European Medical Student Association. Available at: https://www.researchgate.net/publication/364097927_Medical_Science_101_Booklet

2- COVID-19 Information Project (COVID-19 Bilgi Seferberliği Projesi), as Volunteer Translator, Available at:

https://www.istanbul.edu.tr/tr/content/covid-19-bilgilendirme-sayfasi/bilgi-seferberligi-projesi-cevirileri

1- Karagöl, T. and Karagöl, A. (2018). Multipl sklerozun olası tedavisi için in silico makromolekül dizaynı ve hesaplamalı analizi. [In silico macromolecule design and computational analysis for possible treatment of multiple sclerosis.], [online] Googlesciencefair.com. Available at: https://www.googlesciencefair.com/projects/2018/db7a23df00c2891d75b5a625e5d9

Talks & symposium proceedings

34. The Protein Society Annual Symposium, Boston, USA - Karagöl Taner, Karagöl Alper, Shuguang Zhang (2026). Systematic Redesign of Synaptic Vesicle Proteins into Water-Soluble Variants via the QTY-Code Reveals Key Conformational and Evolutionary Dynamics (Award Winner)

33. The Protein Society Annual Symposium, Boston, USA - Karagöl Taner, Karagöl Alper, Shuguang Zhang (2026). Multi-Level Comparative Genomic Analysis Reveals Functional Influence of Truncated Isoforms in Glutamate Transporter Genes (Award Winner)

32. 12th European Academy of Neurology Annual Congress. Geneva, Switzerland. - Karagöl Taner, Karagöl Alper (2026). Lipid Induced Energetic Lability in Serotonin and Dopamine Transporter Assembly Could Be Resisted by Truncation Isoforms.

31. 12th European Academy of Neurology Annual Congress. Geneva, Switzerland. - Karagöl Taner, Karagöl Alper (2026). Reverse-QTY Engineering Converts Soluble Glutamate Transporter Isoforms into High-Affinity Inhibitors.

30. 2026 European Human Genetics Conference organized by the European Society of Human Genetics (ESHG). Gothenburg, Sweden. - Karagöl Taner, Karagöl Alper (2026) Generative Design of Splice Variant Analogs Identifies a Critical Chain Length Threshold for Glutamate Transporter Assembly Loss-of-Function (Poster)

29. 2026 European Human Genetics Conference organized by the European Society of Human Genetics (ESHG).Gothenburg, Sweden. - Karagöl Taner, Karagöl Alper (2026) Improved Interpretation of Human Genetic Variation through Dynamics-Aware Evolutionary Profiling (Poster)

28- Karagöl Taner, Karagöl Alper, Li Mengke, Zhang Shuguang (2025). Computational Data Driven Methods In Discovery Of Native Neurological Transporter Modulators. (Speaker) Nature Conferences - AI for Discovery and Research Automation Conference, organized by Nature Machine Intelligence

27. 29th International Medical Sciences Congress organised by Istanbul University. Gül Kaan Murat, Karagöl Taner, Karagöl Alper. A Next-Generation Approach to Neuroinflammation Modulation: Computational Identification of Inhibitory Truncated Isoforms for Neuroimmunological Targets. (Supervisor)

26. 29th International Medical Sciences Congress organised by Istanbul University. Eken Çınar, Karagöl Alper, Karagöl Taner. Acid-Switchable BRC4-Derived Peptides as Selective Rad51 Inhibitors for Sensitization of Homologous Recombination-Proficient Tumors (Supervisor)

25 - 29th International Medical Sciences Congress organised by Istanbul University. Karagöl Taner. Lecture Title: New Horizons in Medical Sciences (Distinguished Speaker)

24- Karagöl Taner, Karagöl Alper (2025). Variant Dynamics of the Molecular Environment. (Speaker) Sixth International Conference on Proteins and Peptides, Structure, Function, and Biotechnology, co-organized by Menicon, MIT, and the University of Geneva, Geneva, Switzerland

23- Karagöl Taner, Karagöl Alper (2025). Evolutionary Dynamics of Membrane Proteins Through Water-Soluble Variants. (Speaker) Sixth International Conference on Proteins and Peptides, Structure, Function, and Biotechnology, co-organized by Menicon, MIT, and the University of Geneva, Geneva, Switzerland

22. Neuroscience 2025 (SfN Annual Meeting). San Diego -Karagöl Alper, Karagöl Taner. Helix-to-β-Sheet Transitions in Glutamate Transporter EAA1 Splice Isoforms Drive Oligomeric Self-Assemblies and Reveal Conserved Evolutionary Motifs (Late-breaking, free-waiver winner)

21. Neuroscience 2025 (SfN Annual Meeting). San Diego -Karagöl Taner, Karagöl Alper. Computational design of lipid-soluble ApoE N-terminal segment using reverse-QTY code (Late-breaking, free-waiver winner)

20- Karagöl Taner Lecture Title: Biological Machines in Molecular Nanotechnology BORASTEM’25 Festival at Marmara University, Istanbul. Public Engagement of Science - (Distinguished Speaker)

19- Karagöl Taner (Speaker) Neuroscience Conference Experiences 10 July 2025 R&D and Innovation Supreme Coordination Office, Istanbul University, Turkey

18- Karagöl Taner, Karagöl Alper, (2025). Water-Soluble QTY Variant of the Gamma-Secretase Complex Provides Insights into Amyloid Precursor Protein Recognition. (Presentation-Oral) 11th European Academy of Neurology Annual Congress. Helsinki, Finland. GRANT WINNER

17- Karagöl Taner, Karagöl Alper (2025). Cross-Reactivity of Glutamate Transporter EAAT1 and Truncated EAAT2 Isoforms Revealed via Structural Neuroinformatics (Presentation-Oral) 11th European Academy of Neurology Annual Congress. Helsinki, Finland. GRANT WINNER

16- Karagöl Taner, Karagöl Alper, (2025). Karagöl Alper, Karagöl Taner. Computational design of lipid-soluble ApoE N-terminal segment using reverse-QTY code. Neuroscience 2025 (SfN Annual Meeting). San Diago, USA. Late-breaking

15- Karagöl Taner, Karagöl Alper, (2025). Karagöl Alper, Karagöl Taner. Helix-to-β-Sheet Transitions in Glutamate Transporter EAA1 Splice Isoforms Drive Oligomeric Self-Assemblies and Reveal Conserved Evolutionary Motifs. Neuroscience 2025 (SfN Annual Meeting). San Diago, USA. Late-breaking

14- Karagöl Taner, Karagöl Alper, (2025). Multi-Level Comparative Genomic Analysis Reveals Functional Influence of Truncated Isoforms in Glutamate Transporter Genes. Sixth International Conference on Proteins and Peptides, Structure, Function, and Biotechnology, co-organized by Menicon, MIT, and the University of Geneva, Geneva, Switzerland (Poster)

13- Karagöl Taner, Karagöl Alper, Perkins S.J. (2025) A Kernel Regression and Analysis of Evolutionary Amino Acid Varieties Reveals Extensive Nodes of Coagulation Factor 9 variants in the development of Hemophilia B (Poster) 2025 European Human Genetics Conference organized by the European Society of Human Genetics (ESHG). Milan, Italy.

12- Karagöl Taner, Karagöl Alper, Spencer H., Perkins S.J. (2025) A genomic and structural analysis provides enhanced insights into molecular mechanisms of hemophilia B. (Poster) 2025 European Human Genetics Conference organized by the European Society of Human Genetics (ESHG). Milan, Italy.

11- Karagöl Taner, Karagöl Alper, Shuguang Zhang (2025). Structural Bioinformatic Studies of Synaptic Vesicle Proteins with Their Alphafold3 Predicted Water-Soluble QTY Variants and Uncovering the T<=>V Co-Evolution - The 2nd Lund Spring Symposium: Enabling Novel Therapeutic Principles. Lund University, Sweden (Poster presentation)

10- Karagöl Taner, Karagöl Alper, Shuguang Zhang (2025). Multi-Level Comparative Genomic Analysis Reveals Functional Influence of Truncated Isoforms in Glutamate Transporter Genes The 2nd Lund Spring Symposium: Enabling Novel Therapeutic Principles. Lund University, Sweden (Poster presentation)

9- Karagöl Alper, Karagöl Taner, Shuguang Zhang (2024). Comparative genomic analysis of glutamate transporters reveals the evolutionary landscape and splicing plasticity of truncated isoforms. Poster at the 2024 KSBNS Annual Meeting co-organized by Korean Society for Brain and Neural Sciences and the Asian-Pacific Society for Neurochemistry. Gyeongju, South Korea. FELLOWSHIP WINNER

8 - Karagöl Taner, Karagöl Alper, Mengke Li, Shuguang Zhang (2024). Inhibitory effects of the truncated isoforms on glutamate transporter oligomerization revealed by the analysis of gene-centric isoform maps. Poster at the 2024 KSBNS Annual Meeting co-organized by Korean Society for Brain and Neural Sciences and the Asian-Pacific Society for Neurochemistry. Gyeongju, South Korea. FELLOWSHIP WINNER

7- Karagöl Taner, Karagöl Alper, Smorodina Eva, Shuguang Zhang (2024, 1-3 March). Structural studies of glutamate transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural QTY-code mutations. Poster presented at the XXI. International IUGEN Winter School on Molecular Biology and Genetics- Istanbul University, Istanbul, Turkey

6- Taner Karagöl, Alper Karagöl, Shuguang Zhang (2024, April). Evolutionary and structural comparison of serotonin, dopamine and norepinephrine transporters and their water-soluble QTY variants. Oral Presentation at the 28th International Medical Sciences Student Congress (IMSSC) -Istanbul University, Istanbul Turkey

5- Karagöl Alper, Karagöl Taner, Smorodina Eva, Shuguang Zhang (2023). Structural bioinformatics studies of glutamate transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F. Poster presented at the fifth International Conference on Proteins and Peptides, Structure, Function, and Biotechnology, co-organized by Menicon, MIT, and the University of Geneva, Geneva, Switzerland

4- Karagöl, H.A. and Karagöl, M.T. (2018).In silico macromolecule design and computational analysis for possible treatment of multiple sclerosis [Multipl sklerozun olası tedavisi için in silico makromolekül dizaynı ve hesaplamalı analizi]. Attended to Google Science Fair 2018-2019.

3- Karagöl, H.A. and Karagöl, M.T. (2017). In silico macromolecule design and competition analysis for treatment of multiple sclerosis [Multiple Skleroz Hastalığının Olası Tedavisi için in silico Makromolekül Dizaynı ve Hesaplamalı Analizi]. Presentation to BAYER - Turkey Science Projects competition

2- Karagöl, H.A. and Karagöl, M.T. (2017). Multiple Skleroz Hastalığının Araştırılmasında Moleküler Modellemenin Kullanımı [Utilization of molecular modeling in Multiple Sclerosis research], 49th TUBITAK (Scientific and Technological Research Council of Turkey) Research Projects competition. https://www.tubitak.gov.tr/en/competitions/content-2204-a-high-school-students-research-projects-competition

1- Educational Presentations on Endocrinology and Computational Biology (2020-2024), Istanbul University Student Scientific Research Club.

Selected honours & awards

Protein Society Young Investigator Travel Award (2026) : Granted by The Protein Society for the upcoming Annual Symposium in Boston.

Scientific Research Award in Health Sciences (2026) : Awarded by the Istanbul University Rectorate for outstanding contributions to biomedical research.

Dean’s Award for Scientific Excellence 2025, Istanbul University. This recognition is reserved for top-performing students who have demonstrated outstanding research achievements during medical training. Issued for my work on "Developing New Therapeutic Strategies Targeting the Molecular Architecture of Neuronal Transporters”.

Ministry of Industry and Technology, Turkish Patent Office PatentleTürkiye Grants awarded for my patents: "Method for Designing Ph-Specific Proteins Using Evolutionary Informed Sequential Single Base Substitutions.", "Regulation of Immune Activation and Inflammatory Response with STING Truncated Isoform for The Treatment of Autoimmune Diseases and Inflammation.", "Inhibition of Snare Complex Formation and VAMP2 Dimerization by The VAMP2 Truncated Isoform, Targeting Pain Management, Neuromuscular Blockade, and Synaptic Modulation.

The European Academy of Neurology (2025) - Congress Bursary Awarded to my work titled "Cross-Reactivity of Glutamate Transporter EAAT1 and Truncated EAAT2 Isoforms Revealed via Structural Neuroinformatics".

Scientific and Technological Research Council of Turkey, Scientist Support Programs - 2224 International Scientific Meetings Fellowship Program (2024) for “presenting proceedings in scientific meetings abroad to share their original studies with the world of science”. - Fellowship

Erich Frank Scholarship (Alternate Recipient) – Erich-Frank-Gesellschaft, Universität München, Germany (2022). - Recognition of academic merit, to conduct an internship in Germany. The award named after Prof. Dr. med. Ephraim (Erich) Frank (1884–1957), a physician who modernized internal medicine in Istanbul. (not attended as alternate recipient in the internship, pursued another opportunity).

Scientific and Technological Research Council of Turkey (TUBITAK) 25th Biology Olympiad 13 May 2017: first place🥇in the Marmara Region (including Istanbul and Bursa), fifth in Turkey

Istanbul University Istanbul Medical Faculty English Program, settled with honors (top 15, each year >450 students enroll to medical program)

National Higher Education Institutions Exam (YKS) 2018 - top 0.02% out of 2,381,090

Graduated from the high school summa cum laude. High school, top university entrance 🥇

BAYER - Turkey High School Science Projects competition Certificate of Achievement (Jan 2017)

Several Medical - Undergraduate Educational Scholarships 2018 – 2026

Republic of Turkey Ministry of National Education - 2011 Scholarship exam🏅 for Primary and secondary education institutions - Scholarship (2012 – 2018) Scholarship Duration: 7 years